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KMID : 0381120170390030331
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Genes and Genomics
2017 Volume.39 No. 3 p.331 ~ p.340
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Associations of MMP-2 -1306 C/T and MMP-9 -1562 C/T polymorphisms with breast cancer risk among different populations: a meta-analysis
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Han Meng
Yang Qingfeng
Feng Kai
Li Rongping
Ren Jia
Wei Liguang
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Abstract
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The meta-analysis aims to investigate association between two matrix metalloproteinases (MMPs) polymorphisms (MMP-2 -1306 C/T and MMP-9 -1562 C/T) and breast cancer risk. Eligible studies were retrieved from relevant databases, based on predefined criteria. Quality assessment was evaluated by Newcastle-Ottawa Scale. Odds ratio (OR) with its 95% confidence interval (CI) was selected as the effect size for the meta-analysis. As a result, 13 studies were included. MMP-2 -1306 C/T polymorphism was not significantly associated with breast cancer risk under all genetic models (P > 0.05). However, subgroup analysis stratified by ethnicity showed a significant association between MMP-2 -1306 C/T polymorphism and reduced breast cancer risk in Asian populations under allelic model (OR 0.60, 95% CI 0.39-0.90, P = 0.02) and dominant model (OR 0.55, 95% CI 0.34-0.89, P = 0.02). MMP-9 -1562 C/T polymorphism was significantly related to increased breast cancer risk under allelic model (OR 1.50, 95% CI 1.06-2.12, P = 0.02), additive model (OR 1.45, 95% CI 1.02-2.05, P = 0.04) and recessive model (OR 1.54, 95% CI 1.13-2.12, OR 0.007). A significant association between MMP-9 -1562 C/T polymorphism and increased breast cancer risk in Caucasian was detected under most of the genetic models (P < 0.05). MMP-2 -1306 C/T polymorphism might be significantly associated with reduced breast cancer risk in Asian, while MMP-9 -1562 C/T might be closely related to increased breast cancer risk, especially in Caucasian.
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KEYWORD
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MMP-2 -1306 C/T, MMP-9 -1562 C/T, Breast cancer, Polymorphism, Meta-analysis
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